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KMID : 0939920080400030121
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대한암학회지
2008 Volume.40 No. 3 p.121 ~ p.126
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Clinical Correlation between Brain Natriutetic Peptide and Anthracyclin-induced Cardiac Toxicity
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Lee Ho-Sup
Sohn Chang-Bae
Shin Seong-Hoon
Kim Yang-Soo
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Abstract
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Purpose: Anthracycline can effectively treat hematologic malignancies, but has significant risk of cardiotoxicity. We measured the clinical correlation between brain natriuretic peptide (BNP) and anthracycline-induced cardiotoxicity.
Materials and Methods: Between March 2005 and March 2007, 86 patients with acute leukemia, malignant lymphoma, or multiple myeloma receiving systemic chemotherapy with anthracycline were enrolled in the Department of Hemato-oncology, Kosin University Gospel Hospital. We investigated the relationship between BNP level and cardiotoxicity through echocardiography, electrocardiography, BNP levels, and symptoms of heart failure at each chemotherapy cycle.
Results: Of the 86 participants (mean age, 48.5 years; range 20∼65 years), cardiotoxicity developed in 21 pa-tients (24.4%), with 2 patients showing arrhythmia only, 17 patients with transient aspects of heart failure, and 2 patients with chronic heart failure. Cardiotoxicity related to serum BNP level, age, cumulative dose of anthracycline, accompanying chronic disease, and elevated level of troponin-I. Heart failure was more common if BNP levels reached 100 pg/ml at least once.
Conclusions: The clinical correlation between BNP and cardiotoxicity was significant in patients with systemic anthracycline chemotherapy. A prospective clinical trial will be needed to identify the causal relationship between serum BNP level and cardiotoxicity. (Cancer Res Treat. 2008;40:121-126)
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KEYWORD
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Hematologic neoplasms, Anthracycline, BNP, Cardiac toxicity
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